Every year since the release of Ornellaia 2006 a contemporary artist has designed a site-specific work of art for the estate and a set of limited-edition labels, inspired by a word chosen by the Estate Director to describe the character of the new vintage.

The Vendemmia d’Artista project involves the limited-edition production of 111 large-format bottles (100 Double Magnums, 10 Imperials and 1 Salmanazar), which are numbered and signed personally by the artist. Since 2012, every case of Ornellaia has included one bottle featuring a label created by the artist.
Collectors around the world compete for these bottles, most of which are sold during an annual charity auction to support the world of art.

Since 2019, the profits made from the Vendemmia d’Artista project are donated to the Solomon R. Guggenheim Foundation’s Mind’s Eye program, which helps blind or low-vision people experiment art by using all other senses.
Donations from the Ornellaia Vendemmia d’Artista project have allowed the Mind's Eye program to expand through virtual programs. Digitalization has enabled Mind's Eye to reach a vast audience from many countries around the world through the “Verbal Descriptions” that recreate the visual experience of the artwork.